2019 Research Support
A $30,000 grant was awarded to help Dr Locke Karriker and various co-investigators at Iowa State University answer the question, “Does knowledge of testing procedures or the format of culture and susceptibility reports from veterinary diagnostic laboratories influence antimicrobial selection decisions?” The two objectives of the study are to determine if training about how laboratory susceptibility results are generated changes antimicrobial selection, and to determine if the format and context of antimicrobial susceptibility reports changes antimicrobial selection. Results of the study will be disseminated through veterinary continuing education, peer-reviewed publication, and updated professional curriculum. Data from this study may support further studies aimed at influencing behaviors that could impact antimicrobial resistance. Second Quarterly Report: Are antimicrobial selection decisions influenced?
Dr Fabio Vannucci and co-investigators at the University of Minnesota were awarded $19,700 to fund the project, “Development of a diagnostic platform for in situ detection and subtyping of PRRSV within histological lesions.” The goals of the project are to develop and validate a novel RNA-in situ hybridization (RNA-ISH) for detection and genotyping PRRSV strains in lung lesions, to evaluate the analytical performance and agreement between PRRSV ORF5 sequences detected by RNA-ISH in lung lesions and by classical sequencing obtained from tissue homogenate, and to differentiate wild-type PRRSV from vaccine strain in lung tissues of animals naturally infected during outbreak scenarios. The research will offer a rapid diagnostic tool to genetically characterize PRRSV strains in association with histopathological lesions.
The Foundation granted $10,300 to Dr Hans Coetzee from Kansas State University to fund the proposal, “Evaluating the plasma pharmacokinetics, efficacy and tissue residues of oral firocoxib following transmammary delivery from sows to piglets.” He and co-investigators will describe the pharmacokinetics (PK) and bioavailability of oral firocoxib in sows, develop and validate a drug regimen for transmammary delivery of oral firocoxib from sows to piglets at processing, and describe the tissue residue concentrations of firocoxib in sows and piglets following oral administration. This research will optimize the dose, duration, and frequency of administration of oral firocoxib in sows for transmammary delivery to piglets prior to processing so that this can be safely and effectively implemented on swine production systems. Final Report: Evaluating the plasma pharmacokinetics, efficacy and tissue residues of oral firocoxib following transmammary delivery from sows to piglets.
2018 Research Support
A $30,000 grant was awarded to fund the project “Refining PRRSV classification system and sequencing reports to better characterize genetic diversity and relatedness of PRRSV,” to be carried out by Dr Jianqiang Zhang and co-investigators at Iowa State University. The study will analyze an ISU Veterinary Diagnostic Laboratory dataset of 37,345 PRRSV-2 (North American type) ORF5 sequences spanning 2000 through 2017, in order to refine a previously described lineage classification system. The resulting, thorough phylogenetic lineage classification system will 1) help describe genetic diversity and relatedness of PRRSV-2 in the U.S, 2) improve sequence reports of diagnostic cases, and 3) determine the prevalence and geographic distribution of PRRSV-2 in the U.S in regards to lineages and RFLP patterns. It is hoped that the classification system will provide a basis for further characterization of the antigenic relationship and cross-protection between different PRRSV-2 lineages in future studies. Interim Report: Refining PRRSV classification system and sequencing reports to better characterize genetic diversity and relatedness of PRRSV
Dr Daniel Linhares and various co-investigators at Iowa State University received funding for two separate projects. The foundation awarded $12,582 for Dr Linhares’ proposal to study “the effect of attenuated PRRSV mass vaccination on subsequent downstream mortality.” The goal of the project is to assess the impact of quarterly MLV mass vaccination of PRRSV-stable breeding herds on grow-to-finish mortality using natural experiments under field conditions. The results will provide information to help swine veterinarians make better informed decisions regarding the use of PRRSV MLV vaccine and other interventions in the sow herd to reduce wean-to-market mortality. Final Report: The effect of attenuated PRRSV mass vaccination on subsequent downstream mortality
The foundation granted an additional $8,418 to carry out Linhares’ second proposal, “Monitoring ISU VDL data for signs of emerging diseases.” This project will develop and incorporate analytical tools for the automated detection of significant changes in test results of major swine pathogens, allowing early identification of disease threats affecting swine. Final Report: Monitoring ISU VDL data for signs of emerging diseases
Dr Perle Boyer at the University of Minnesota received a grant of $9000 to fund her proposal to develop day-1 competencies for swine veterinary graduates. The project will be carried out by a faculty task force at the University of Minnesota, with input by swine practitioners from across the US and Canada. The resulting prioritized list of skills will be published and shared with other colleges of veterinary medicine, and made available to veterinary students at the AASV annual meeting and on the AASV website. The research has been published in Education in The Health Professions. Final Report: Developing day-1 competencies for swine veterinary graduates
2017 Research Support
A grant of $30,000 was awarded to Dr Jianqiang Zhang and co-investigators at Iowa State University to fund the project “Comparison of PRRSV virus isolation in different cell lines towards improving success of isolating PRRSV from clinical samples.” The study will use serum, lung, and oral fluid samples to compare the use of 2 different cell lines for virus isolation. The project will also evaluate the correlation of PRRSV concentration, genetic lineage, and specimen type to virus isolation success. The goal is to improve the success of PRRS virus isolation attempts when requested by swine practitioners for autogenous vaccine production or further characterization. Final Report: Comparison of PRRSV virus isolation in different cell lines towards improving success of isolating PRRSV from clinical samples
Dr Daniel Linhares at Iowa State University, along with co-investigators at ISU and Carthage Veterinary Service Ltd, was awarded a grant of $11,824 to investigate the effect of attenuated PRRSV on short-term and long-term whole herd productivity. The primary objective of the study is to investigate and measure the impact of MLV vaccine on key breeding herd performance parameters, using natural experiments under field conditions. It is anticipated this information will be used with existing economic models to assist swine veterinarians in making informed decisions regarding the use of PRRSV MLV vaccine as a preventive tool. Final Report: Assessment of immediate production impact following attenuated PRRS virus vaccination in endemically infected breeding herds.
2016 Research Support
The AASV Foundation awarded a grant of $17,500 to Dr Steve Tousignant at Swine Vet Center to fund a proposal designed to determine the sero-prevalence of Seneca Valley A virus in a convenience sample collected from U.S. sow farms. The research will also explore risk factors associated with the presence of the SVA virus in sow farms. Final Report: Sero-prevalence of Senecavirus A and risk factors among a convenience sample of sow farms in the United States
Dr Scott Dee at Pipestone Veterinary Services was awarded a grant of $15,000 to assist with funding for a study to evaluate a shipping model using viral proxies to investigate whether foreign animal diseases could survive in feed ingredients shipped from Asia to the US. The study will also evaluate whether two chemical mitigants could reduce the risk of pathogen survival. Presented at the 2017 AASV Annual Meeting: Modeling the transboundary survival of foreign animal disease pathogens in contaminated feed ingredients. Final Report: Modeling the transboundary survival of foreign animal disease pathogens in contaminated feed ingredients
The foundation allocated $15,000 to fund a proposal submitted by Dr Mike Murtaugh at the University of Minnesota toward designing a challenge-free model to predict vaccine efficacy. Presented at the 2017 AASV Annual Meeting: B-cell tetramer to evaluate memory immune response to PRRSV. Final Report: Toward animal challenge-free prediction of vaccine efficacy
$12,500 was awarded to Dr Derald Holtkamp at Iowa State University to support a study to compare the effectiveness of standard entry versus bench entry biosecurity protocols in a commercial swine facility. Presented at the 2017 AASV Annual Meeting: Comparison of standard and bench entry protocols for prevention of environmental contamination due to personnel entry in a commercial swine facility. Final Report: Comparison of standard and bench entry protocols for prevention of environmental contamination due to personnel entry in a commercial swine facility
2015 Research Support
The AASV Foundation awarded a grant of $7,490 to Dr Paisley Canning at Iowa State University to fund a proposal designed to help address the challenge of providing swine training to interested swine-focused students at veterinary colleges across the country. Dr Canning will develop a network of swine and production animal medicine clubs at veterinary schools for the purpose of transmitting live broadcasts of 3 swine-focused seminars hosted by the ISU AASV Student Chapter to the participating schools. Final Report: Swine Seminar Series
Dr Trevor Schwartz at Suidae Health & Production was awarded a grant of $16,450 to assist with funding for a study on the effect of PEDV vaccination on PEDV-naïive sows and previously PEDV-exposed sows in a controlled PEDV challenge model. The study will compare vaccinated and unvaccinated sow immune response and litter pre-weaning morbidity/mortality in an effort to determine if there is a significant difference between naiive and previously exposed sows, and whether the measured immune response can be correlated with litter pre-weaning morbidity/mortality. Final Report: Evaluation of the effects of PEDV vaccine on PEDV naiive and previously PEDV exposed sows in a challenge model comparing immune response and preweaning mortality
The foundation allocated $15,000 to fund a proposal submitted by Dr Carissa Odland at Pipestone Veterinary Clinic to perform efficacy testing of a novel method of euthanasia of suckling piglets. The ultimate goal is to gain FDA approval of the process in order to provide swine veterinarians and producers with a simple and humane method of euthanizing small piglets. Final Report: Efficacy testing for a novel method for euthanasia of suckling piglets
Eric Bumgardner and Dr Paulraj Lawrence at Newport Laboratories were awarded $21,060 to assist with the development of a bivalent PRRS/PCV2 vaccine capable of inducing broader cross-protection against PRRS. They hope to develop vaccination strategies that can be used in commercial swine herds to protect animals against diverse PRRSV strains and to gain insight into the immunological properties of PRRSV. Interim Report: Bivalent PRRSV/PCV2 vaccine development - Phase 1
2014 Research Support
The AASV Foundation awarded a grant of $30,000 to support a proposal submitted by Dr James Lowe at the University of Illinois. Lowe and fellow investigators will be studying "The effects of cross-fostering strategy on the immune system, microbiome and lifetime growth in pigs with minimal disease loads." By examining the impact of the periparturient acquisition of non-inherited factors on piglet health and performance, their goal is to help shape management practices that improve host robustness in the face of disease challenge. Final Report: Influence of maternal microbial communities on the mucosal microbiome of neonatal pigs.
Dr Darwin Reicks at the Swine Vet Center in St. Peter, Minn, was awarded a grant of $25,000 to study "Porcine epidemic diarrhea virus (PEDV) shedding and contamination potential from infected boars." The project goal is to determine if PEDV can be transmitted in boar semen and if the virus is a fecal contaminant or the result of systemic infection or cellular trafficking from an intestinal infection. Final Report: PED and boars: Research update
A grant of $5000 was awarded to Dr Cate Dewey at the University of Guelph, to fund the proposal, "Reducing pathogen spread during farm feed delivery." One-page briefs will be prepared for major swine pathogens as well as a quick-reference chart summarizing the information. The materials will be peer-reviewed and ultimately shared with AASV members for distribution to producers, feed company personnel and others. Final Report: 2014_Dewey_Reducing_Pathogen_Spread Biosecurity Fact Sheets: Basic Fact Sheets; Detailed Fact Sheets
2013 Research Support
The AASV Foundation has approved support in the amount of $4324 to fund the study, "Comparison of regional limb injection to systemic medication for the treatment of septic lameness in sows." The project coordinator is Dr. Brandon Dominguez at the College of Veterinary Medicine & Biomedical Sciences at Texas A&M University. The project will explore whether regional intravenous limb perfusion of lincomycin HCl provides an improved method for treating sow lameness caused by localized septic conditions, as compared to treating with systemic lincomycin only. Final Report: 2013_Regional Limb Perfusion
The foundation also approved support of up to $6000 for a proposal to host a Dahlem-style workshop on "Disease surveillance in complex production systems," submitted by Drs Eric Neumann (Massey University) and Jeff Zimmerman (Iowa State University). The funding is contingent upon the investigators securing the additional co-funding necessary to conduct the workshop, which is slated to take place in late 2013. Final Report: The workshop was not held; funds were not disbursed.
2012 Research Support
The AASV Foundation is pleased to announce funding for the study, “Applied swine genomics for PRRSv resistance and pathogenesis in the fetus and uterus.” The project proposal, submitted by Dr. Susan Detmer at the University of Saskatchewan, was approved for funding in the amount of $6,000 by the AASV Foundation’s research review committee. The foundation’s support will supplement the project’s primary funding from Genome Canada (co-primary investigator: Dr. John Harding), enabling a graduate student to participate in the data collection and analysis over the summer.Using a reproductive model developed over the past year, the multi-center project will examine the PRRS resistance within sows and fetuses by comparing the genotype of the fetuses and dams to the tissue viral loads and histopathologic lesions in the fetuses and adjacent uterus. Multivariate analysis will be used to estimate potential relationships between predictor variables and the PRRS-resistance score. Additionally, the project will be looking at specifically identified potential markers of PRRS resistance.
Final Report: Using an unprecedented 133 pregnant gilts, 114 PRRSv inoculated and 19 mock-infected on gestation day 85 (±1), the live animal work occurred between April and October 2012. The necropsy was performed on day 21 post-infection, where a team of over 20 people collected samples from the sows and fetuses, which were cataloged and dispersed to collaborators in Canada and the USA. As of January 2014, the uterine tissues were scored using a new scoring system and statistical analysis had been performed. The results of the student’s work was presented as part of the research topics poster session at the 2014 AASV meeting: Relationship of microscopic lesions and viral load in fetal implantation sites for type 2 PRRSv infected pregnant gilts by Novakovic P, Al-Dissi A, Ladinig A, Harding J, and Detmer S. Additional results were reported by the same authors at the 2014 IPVS Congress: Relationship of microscopic lesions and viral load in fetal implantation sites for type 2 PRRSV-infected pregnant gilts.
2011 Research Support
The AASV Foundation is providing support in the amount of $6000 to build an online training module to teach "best practices" for selection, collection, handling, and submission of diagnostic samples, targeted to 4th-year veterinary students. The module will be presented in video formats compatible with iPads and smartphones in addition to traditional desktop computers. The project is underway at Iowa State University under the direction of Drs. Darin Madson, Jason Hocker, and Locke Karriker. Final Report: 2011_DiagnosticSubmissions
2010 Research Support
The AASV Foundation is pleased to announce the funding of research with application to the swine veterinary profession. The foundation’s research review committee selected a proposal submitted by Dr. Cate Dewey for funding in the amount of $5,560.
The foundation’s support will fund efforts at the University of Guelph to expose pre-veterinary and veterinary students to the basics of swine production management and career opportunities in swine medicine. The program will engage two groups of 5 to 6 students in a series of on-farm seminars and group discussions during the 2010-11 school year. The students will have the opportunity to observe and participate in on-farm activities related to each stage of pig development. In addition, they will attend at least one swine continuing education meeting, discuss research published in JSHAP, and meet with swine veterinarians engaged in private practice as well as other swine-related careers. At the conclusion of the program, an exit survey will be administered to determine if the program influenced the students’ decisions regarding swine veterinary medicine. A summary of the findings will be published in the Journal of Swine Health and Production. Final report: 2010_PrevetProgram
2009 Research Support
The Foundation did not extend funding for research in 2009.
2008 Research Support
The AASV Foundation is pleased to announce the selection of three research proposals for funding in 2008. The funding - in the amount of $6000 per proposal - will support research efforts at four Midwest universities.
At the University of Minnesota, work is underway to develop a real-time PCR for the detection of Actinobacillus suis. AASV Foundation support for this project will enable primary investigator Dr. Simone Oliveira to employ a veterinary student to participate in the research effort and submit the results for publication and presentation during the AASV annual meeting. Final report: RT-PCR for A. suis
Drs. Locke Karriker and Alex Ramirez at Iowa State University are leading a project to create a swine medicine field manual. The Foundation funds will assist with the peer review and publication of the first edition of the manual, which consists of a compilation of field diagnostic techniques for swine veterinarians and students. The manual will be produced in electronic as well as print format.
The third project funded by the AASV Foundation involves a joint effort by researchers at Kansas State University and Michigan State University, and private practitioners. The proposal, submitted by Dr. Megan Potter at Kansas State, will explore the use of PCV2 vaccine as a tool in the elimination of PCV2 from infected swine herds. The Foundation contribution will support the diagnostic testing needed to complete the third phase of the study. Final Report: PCV2 Elimination Study
2007 Research Support
The AASV Foundation provided support in the amount of $6000 to investigator Dr. Scott Dee to assist with the compilation of a bilingual PRRS virus biosecurity manual summarizing routes, intervention and monitoring protocols for use on commercial farms. Final report: PRRS Biosecurity Manual (English); PRRS Biosecurity Manual (Spanish)