Evaluation of tylosin tartrate in drinking water for treatment of porcine proliferative enteropathy (ileitis)

M. A. Paradis, DMV; G. E. Pauling, DVM, MSc; J. Brennan, PhD; N. L. Winkelman, DVM; R. N. Bagg, DVM; C. P. Dick, DVM, MSc; J. Wilson, DVM, DVSc, PhD

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Objectives: To evaluate the effectiveness of tylosin tartrate administered via drinking water to pigs orally challenged with Lawsonia intracellularis.

Materials and methods: The study consisted of three treatments (Nonchallenged- unmedicated, Challenged-unmedicated, and Challenged-medicated), with six pens of six pigs per treatment (N = 108 pigs). Pigs 28 days old were challenged orally on Days 0 and 1 with L intracellularis. Drinking water medicated with tylosin tartrate (Tylan Soluble Powder; Elanco Animal Health, Indianapolis, Indiana) was provided to medicated pens Days 10 to 17. Pigs were weighed daily and assigned clinical scores, and feed consumption was measured. At necropsy (Days 17 and 18), gross lesions consistent with porcine proliferative enteropathy (PPE) were recorded, and tissues were collected for histopathologic examination and testing by polymerase chain reaction (PCR).

Results: Among challenged pigs, those medicated with tylosin had lower mean fecal consistency scores (P < .05), fewer pigs per pen with PPE-associated lesions (P < .05), less PCR-positive ileal tissue (P < .05), and better growth parameters (P < .05), compared to unmedicated pigs. Among unmedicated pigs, those challenged with L intracellularis had higher mean fecal consistency scores (P < .05), more pigs per pen with PPE-associated lesions (P < .05), more pigs PCR-positive for L intracellularis (P < .05) and poorer growth parameters (P < .05), compared to nonchallenged pigs.

Implications: This study provides evidence that tylosin tartrate administered in drinking water is effective in reducing clinical signs, lesions, and suppression of growth performance associated with PPE in swine challenged with L intracellularis.

Keywords: PPE, porcine proliferative enteropathy, tylosin tartrate, growth

RIS citationCite as: Paradis MA, Pauling GE, Brennan J, et al. Evaluation of tylosin tartrate in drinking water for treatment of porcine proliferative enteropathy (ileitis). J Swine Health Prod 2004;12(4):176-181.

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