Plasma concentrations of sodium salicylate in nursery pigs treated orally
Abby R. Patterson; Locke A. Karriker, DVM, MS, Diplomate ACVPM; Michael D. Apley, DVM, PhD, Diplomate ACVCP; Paula M. Imerman, MS, PhD
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Objectives: To determine stability of acetylsalicylic acid (ASA) and sodium salicylate (SS) stock solutions, and to determine plasma concentrations of SS in swine after administration in drinking water.
Materials and methods: Stock solutions of liquid ASA and SS products were placed in a nursery environment for 24 hours (Trial One). Salicylate concentrations were measured at 0, 8, 16, and 24 hours using high pressure liquid chromatography (HPLC). In Trial Two, SS was metered into the drinking water of four groups of pigs in a commercial nursery, at stock solution concentrations of 2268 mg per L (T1), 4913 mg per L (T2), 9827 mg per L (T3), and 19,654 mg per L (T4). Controls received nonmedicated water. Plasma salicylate concentrations in 10 pigs per group were measured at 0, 24, 60, and 72 hours.
Results: Salicylate concentration ranges of stock solutions in Trial One were 4.04 to 4.61 g per L (ASA) and 8.19 to 9.34 g per L (SS). In Trial Two, mean plasma salicylate concentration ranges for treated groups over the 72-hour study were 0.17 to 0.41 mg per L (T1), 0.03 to 1.28 mg per L (T2), 0.44 to 1.41 mg per L (T3), and 0.62 to 7.22 mg per L (T4). Mean concentrations increased at 24 hours post study initiation, then decreased for all treated groups at 60 hours.
Implications: Solubilities of ASA and SS products differ. Sodium salicylate administered via a water-medication system reaches measurable plasma concentrations in nursery pigs. Consistency of dosing may be variable.
Keywords: pharmacology, anti-inflammatory drugs, aspirin
Cite as: Patterson AR, Karriker LA, Apley MD, et al. Plasma concentrations of sodium salicylate in nursery pigs treated orally. J Swine Health Prod 2007;15(3):146-151.
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