Effects of Mycoplasma hyopneumoniae vaccination in pigs co-infected with M hyopneumoniae and porcine circovirus type 2
Vicki J. Rapp-Gabrielson, MS, PhD; Thayer Hoover, DVM; Steve Sornsen, DVM, MS; Lyle Kesl, DVM, PhD; Lucas Taylor, MS; Rika Jolie, DVM, PhD, MBA; Paul Runnels, DVM, PhD; Daniel Weigel, MS, PhD; Shan Yu, DVM, PhD; Tanja Opriessnig, DVM, PhD; Kristin Ruebling-Jass, MS; Erin Strait, DVM; Patrick G. Halbur, DVM, PhD
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Objectives: To evaluate clinical and production parameters in pigs vaccinated with commercially available Mycoplasma hyopneumoniae (M hyo) bacterins, then co-infected with M hyo and porcine circovirus type 2 (PCV2).
Materials and methods: Weaned pigs (n = 296) were each vaccinated with one of three M hyo bacterins or a placebo and challenged 3 and 5 weeks after the second vaccination with M hyo and PCV2, respectively. A subset of pigs, necropsied 2 or 4 weeks after PCV2 challenge, were evaluated for clinical signs, lesions, PCV2 serum levels, and M hyo in bronchial alveolar lavage fluids. Antibody titers to M hyo and PCV2 and average daily gain (ADG) were determined periodically during the trial. Estimated carcass value was determined at market weight.
Results: In the placebo group, the challenge caused severe respiratory disease associated with M hyo and PCV2. There was no evidence of vaccine-enhanced PCV2 associated disease, in that the vaccine and placebo groups did not differ in PCV2 serum levels, severity of PCV2 lesions, or incidence of PCV2-associated disease. Vaccinated groups had lower lung lesion scores at necropsy 2 weeks post challenge and higher body weights and ADG at the study conclusion.
Implications: When short-term clinical and long-term production parameters are evaluated, control of M hyo infection by M hyo vaccination is an important tool in reducing respiratory disease and production losses in herds infected with both PCV2 and M hyo. Under the conditions of this study, M hyo vaccination does not enhance disease associated with PCV2 infection.
Keywords: Mycoplasma hyopneumoniae, porcine circovirus type 2, co-infection, postweaning multisystemic wasting syndrome, PCV, PMWS
Cite as: Rapp-Gabrielson VJ, Hoover T, Sornsen S, et al. Effects of Mycoplasma hyopneumoniae vaccination in pigs co-infected with M hyopneumoniae and porcine circovirus type 2. J Swine Health Prod 2008;16(1):16-26.
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