Abstract:

Investigation of tiamulin hydrogen fumerate in-feed antibiotic for the control of porcine respiratory disease complex that includes Mycoplasma hyopneumoniae

Elizabeth Roberts, DVM, PhD, Diplomate ABT; James Mark Hammer, DVM; Kelly Lechtenberg, DVM, PhD; Linda Roycroft, MA; Stephen King, MSc

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Objective: To evaluate tiamulin hydrogen fumerate (THF) as an in-feed antibiotic for control of porcine respiratory disease complex (PRDC) that includes infection with Mycoplasma hyopneumoniae (M hyo).

Materials and methods: Two studies were performed to evaluate PRDC-associated clinical signs and pneumonia lesion resolution in pigs treated with THF (Denagard 10; Novartis Animal Health US, Greensboro, North Carolina) at 137.5 and 165.0 ppm. Study One evaluated nursery pigs multi-sourced from two herds affected by PRDC. In Study Two, single-sourced naive pigs were challenged with M hyo.

Results: In Study One, nursery pigs exhibiting clinical signs of PRDC and treated with THF at 165.0 ppm showed significantly better treatment success than did controls, defined as body temperature < 40ºC and respiratory and depression scores < 2 on Day 17 (P < .001), with lower total percent pneumonia lesions
(P < .001) and mortality (P < .05). In the THF 137.5 ppm group, total percent pneumonia lesions (P < .001) and mortality (P < .05) were lower than in controls. Treatment success did not differ between the THF 137.5 ppm group and the controls. In Study Two, total percent pneumonia lesions was lower in the THF 165.0 ppm group (11.76%; P < .001) and 137.5 ppm group (16.02%; P < .05) than in controls (22.35%).

Implication: In-feed THF produces a clinical benefit in pigs experiencing PRDC or experimentally challenged with M hyo.

Keywords: tiamulin hydrogen fumerate, porcine respiratory disease complex, Mycoplasma hyopneumoniae, PRDC

Cite as: Roberts E, Hammer JM, Lechtenberg K, et al. Investigation of tiamulin hydrogen fumerate in-feed antibiotic for the control of porcine respiratory disease complex that includes Mycoplasma hyopneumoniae. J Swine Health Prod 2011;19(4):218-225.

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