Genetic line influences pig growth rate responses to vaccination for porcine circovirus type 2
Megan L. Potter, DVM, PhD; Lisa M. Tokach, DVM, Diplomate ABVP; Steve S. Dritz, DVM, PhD; Steven C. Henry, DVM, Diplomate ABVP; Joel M. DeRouchey, MS, PhD; Mike D. Tokach, MS, PhD; Robert D. Goodband, MS, PhD; Jim L. Nelssen, MS, PhD; Raymond R. R. Rowland, MA, PhD; Richard A. Hesse, MS, PhD; Richard Oberst, DVM, PhD; Joseph Anderson; Michael Hays
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Objectives: To compare the effects of porcine circovirus type 2 (PCV2) vaccination on growth rate, backfat depth, and loin depth of pigs in a high-health herd which contained different genetic lines.
Materials and methods: A total of 454 pigs (20.6 Â± 1.98 days of age; 6.1 Â± 1.27 kg body weight) were used in a 130-day randomized controlled field trial. Genetic designations were AÃA (Duroc line), BÃB (synthetic White Pietrain line), AÃB, and BÃA. Pigs were randomly assigned to vaccination treatments (Vaccinated or nonvaccinated Control) within litter by gender (boar or gilt). Vaccinated pigs received two doses of a PCV2 vaccine at 3 and 5 weeks of age. Serum samples were collected and pigs were individually weighed on Days 0 (weaning), 40, and 130 to determine PCV2 viral load, antibody levels, and average daily gain (ADG). Data were analyzed from 417 pigs with complete growth records.
Results: The greater ADG from Day 0 to Day 130 for Vaccinated pigs depended on the genetic line (genetic line-by-vaccination interaction; P < .05). The mean weight difference between Vaccinated and Control pigs was almost four times greater in the AÃA pigs than in the BÃB pigs on Day 130. On average, compared with Control pigs, Vaccinated pigs had lower serum PCV2 viral load levels on Days 40 and 130 (P < .001).
Implications: Pig genetic line affects growth rate response to PCV2 vaccination and should be considered a risk factor for circoviral disease expression.
Keywords: genetic line, growth, porcine circovirus type 2, vaccine
Cite as: Potter ML, Tokach LM, Dritz SS, et al. Genetic line influences pig growth rate responses to vaccination for porcine circovirus type 2. J Swine Health Prod 2012;20(1):34-43.
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