The effect of dose and route of administration of prostaglandin F2-alpha on the parturient response of sows
Roy N. Kirkwood, DVM, PhD; Philip A. Thacker, PhD; Frank X. Aherne,PhD; Laksiri A. Goonewardene, PhD
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Objective-In two experiments, we tested the effect of dose and route of administration of prostaglandin F2-alpha (PGF2-alpha) on the farrowing response of sows.
Design and procedure-In experiment 1, we injected 25% of a full dose into the vaginal mucosa. In experiment 2, we injected cloprostenol perianally.
Results-We found that as many sows farrowed within a 48-hour period following injection into the vaginal mucosa of 25% of the recommended dose as farrowed following intramuscular (IM) injection of the full dose. Experiment 2 confirmed the efficacy of the 25% dose when injected vaginally. However, when sows were injected perianally with cloprostenol, the 50% dose proved relatively effective, but fewer farrowed within the 48-hour period when a 25% dose was used.
Implications-Twenty-five percent of the recommended dose of PGF2a, when administered vaginally, was equally as effective as the full recommended dose administered IM. However, no more than 65% of sows farrowed the day after a PGF2a, regardless of dose or route of administration.
Keywords: prostaglandin F2-alpha, administration
Cite as: Kirkwood RN, Thacker PA, Aherne FX, Goonewardene LA.. The effect of dose and route of administration of prostaglandin F2-alpha on the parturient response of sows. J Swine Health Prod 1996;4(3):123-126.
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