TY - JOUR AU - Spiehs, MJ AU - Shurson, GC AU - Johnston, LJ TI - Effects of two direct-fed microbials on the ability of pigs to resist an infection with Salmonella enterica serovar Typhimurium T2 - Journal of Swine Health and Production JF - Journal of Swine Health and Production J2 - JSHAP SN - 1537-209X DP - American Association of Swine Veterinarians PB - American Association of Swine Veterinarians DA - 2008/Jan// PY - 2008 VL - 16 M1 - 1 IS - 1 M2 - 27 SP - 27-36 L2 - https://www.aasv.org/shap/issues/v16n1/v16n1p27.htm UR - https://www.aasv.org/shap/abstracts/abstract.php?v16n1p27 L1 - https://www.aasv.org/shap/issues/v16n1/v16n1p27.pdf KW - swine KW - Salmonella enterica KW - Typhimurium KW - direct-fed microbials KW - food safety KW - acute phase protein N2 - Objective: To evaluate the effects of direct-fedmicrobials (DFMs) containing either Bacillus licheniformisand Bacillus subtilis or Enterococcus faecium on theability of finisher pigs to resist a Salmonella serovarTyphimurium infection.Materials and methods: Forty finishing pigs were used ina 12-day disease challenge study. Dietary treatments included noDFM (Control; 20 pigs), DFM provided in drinking water (Efaecium), or DFM provided in feed (Bacillus). TenControl pigs were not challenged with SalmonellaTyphimurium; the remaining 30 pigs were inoculated on Day 0. Fecalsamples were cultured for Salmonella Typhimurium on Days 0to 5, 9, and 12. Serum haptoglobin (Hp), α1-acid glycoprotein(AGP), IgG, and IgM concentrations were measured. Pigs wereeuthanized on Day 12, and tissue and digesta were tested forpresence and numbers of salmonellae.Results: Pigs challenged with SalmonellaTyphimurium had looser stools (P < .05), greater fecalshedding of salmonellae on Days 2, 3, 4, and 5 (P < .05),and higher serum Hp concentrations on Day 7(P < .05) than nonchallenged pigs. Serum AGP,IgG, and IgM concentrations were similar between challenged andnonchallenged pigs on all days. Fecal and tissue concentrations ofSalmonella Typhimurium and serum Hp, AGP, IgG, and IgMconcentrations were similar among challenged groups fed the threedietary treatments.Implications: Under the conditions of this study, DFMsare not effective in reducing prevalence of SalmonellaTyphimurium in feces, gastrointestinal contents, or tissues, ordecreasing the number of salmonellae shed. ER -