TY - JOUR AU - Desrosiers, R AU - Clark, E AU - Tremblay, D TI - Use of a one-dose subunit vaccine to prevent losses associated with porcine circovirus type 2 T2 - Journal of Swine Health and Production JF - Journal of Swine Health and Production J2 - JSHAP SN - 1537-209X DP - American Association of Swine Veterinarians PB - American Association of Swine Veterinarians DA - 2009/May// PY - 2009 VL - 17 M1 - 3 IS - 3 M2 - 148 SP - 148-154 L2 - https://www.aasv.org/shap/issues/v17n3/v17n3p148.html UR - https://www.aasv.org/shap/abstracts/abstract.php?v17n3p148 L1 - https://www.aasv.org/shap/issues/v17n3/v17n3p148.pdf KW - swine KW - porcine circovirus associated disease KW - porcine circovirus vaccine KW - mortality KW - serological response KW - PCV2 KW - PCVAD N2 - In a commercial swine herd in eastern Canada, porcine circovirusassociated disease (PCVAD) had been occurring for about 18 monthswhen a test vaccine was introduced. Pigs were affectedapproximately 3 weeks after entering the finishing units. A totalof 3852 pigs were enrolled in the study. Half of the pigs wererandomly selected to be vaccinated at 19 to 59 days of age with aone-dose porcine circovirus type 2 (PCV2) vaccine (IngelvacCircoFlex; Boehringer Ingelheim Vetmedica Inc, St Joseph,Missouri). The other half of the pigs were injected on the same daywith sterile water (controls). No local or systemic adversereactions were observed. The study pigs were placed in fourdifferent finishing units and in each one, mortality wassignificantly lower in vaccinated pigs (P < .01).Enlarged lymph nodes and white spots on the kidneys were among themost frequent lesions suggesting PCVAD. Splenic infarcts wereobserved in a few pigs. Results of two different serological testsshowed that pigs could be effectively vaccinated in the presence ofmaternal immunity. There was no correlation between seroconversion(in response to vaccination) and protection. ER -