TY - JOUR AU - Potter, ML AU - Tokach, LM AU - Dritz, SS TI - Genetic line influences pig growth rate responses to vaccination for porcine circovirus type 2 T2 - Journal of Swine Health and Production JF - Journal of Swine Health and Production J2 - JSHAP SN - 1537-209X DP - American Association of Swine Veterinarians PB - American Association of Swine Veterinarians DA - 2012/Jan// PY - 2012 VL - 20 M1 - 1 IS - 1 M2 - 34 SP - 34-43 L2 - https://www.aasv.org/shap/issues/v20n1/v20n1p34.html UR - https://www.aasv.org/shap/abstracts/abstract.php?v20n1p34 L1 - https://www.aasv.org/shap/issues/v20n1/v20n1p34.pdf KW - swine KW - genetic line KW - growth KW - porcine circovirus type 2 KW - vaccine N2 - Objectives: To compare the effects of porcine circovirus type 2 (PCV2) vaccination on growth rate, backfat depth, and loin depth of pigs in a high-health herd which contained different genetic lines.Materials and methods: A total of 454 pigs (20.6 ± 1.98 days of age; 6.1 ± 1.27 kg body weight) were used in a 130-day randomized controlled field trial. Genetic designations were A×A (Duroc line), B×B (synthetic White Pietrain line), A×B, and B×A. Pigs were randomly assigned to vaccination treatments (Vaccinated or nonvaccinated Control) within litter by gender (boar or gilt). Vaccinated pigs received two doses of a PCV2 vaccine at 3 and 5 weeks of age. Serum samples were collected and pigs were individually weighed on Days 0 (weaning), 40, and 130 to determine PCV2 viral load, antibody levels, and average daily gain (ADG). Data were analyzed from 417 pigs with complete growth records.Results: The greater ADG from Day 0 to Day 130 for Vaccinated pigs depended on the genetic line (genetic line-by-vaccination interaction; P < .05). The mean weight difference between Vaccinated and Control pigs was almost four times greater in the A×A pigs than in the B×B pigs on Day 130. On average, compared with Control pigs, Vaccinated pigs had lower serum PCV2 viral load levels on Days 40 and 130 (P < .001).Implications: Pig genetic line affects growth rate response to PCV2 vaccination and should be considered a risk factor for circoviral disease expression. ER -