Emergence of Plasmid-mediated Colistin Resistance Mechanism MCR-1 in Animals and Human Beings in China: A Microbiological and Molecular Biological Study
November 25, 2015 —
Background Until now, polymyxin resistance has involved chromosomal mutations but has never been reported via horizontal gene transfer. During a routine surveillance project on antimicrobial resistance in commensal Escherichia coli from food animals in China, a major increase of colistin resistance was observed. When an E coli strain, SHP45, possessing colistin resistance that could be transferred to another strain, was isolated from a pig, we conducted further analysis of possible plasmid-mediated polymyxin resistance. Herein, we report the emergence of the first plasmid-mediated polymyxin resistance mechanism, MCR-1, in Enterobacteriaceae.
Interpretation The emergence of MCR-1 heralds the breach of the last group of antibiotics, polymyxins, by plasmidmediated resistance. Although currently confined to China, MCR-1 is likely to emulate other global resistance mechanisms such as NDM-1. Our findings emphasise the urgent need for coordinated global action in the fight against pan-drug-resistant Gram-negative bacteria.
Yi-Yun Liu, et al; Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study; The Lancet Infectious Diseases; Published online: 18 November 2015. DOI: http://dx.doi.org/10.1016/S1473-3099(15)00424-7
- Next story: Over the Levee and Through the Quarter
- Next in category: Economics of Antibiotic Use in U.S. Livestock Production
- Previous in category: Effects of Group Housing after Weaning on Sow Welfare and Sexual Behavior
- Previous story: PADRAP Plays a Role in SVA Outbreak Investigations