Efficacy of tilmicosin, and a combination of tylosin and sulfamethazine, for control of swine atrophic rhinitis involving infection with toxigenic Pasteurella multocida type D
Lennart Bäckström, DVM, PhD; Jeannette McDonald, DVM; Michael T. Collins, DVM, PhD; Wen-Bin Chung, DVM, PhD; Thomas R. Shryock, PhD; and Earl E. Ose, MS
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Tilmicosin, 20-deoxo-20-(3,5-dimethylpiperidin-1-yl) desmycosin, is a new semi-synthetic mocrolide antibiotic that has been reported to have excellent in vivo and in vitro effect against both Gram-positive and Gram-negative bacteria, including Pasteurella multocida. In its injectable form, under the trademark of Micotil(R), is approved for control of shipping fever/pasteurellosis in cattle. In swine, parenterully administered tilmicosin is toxic even at low dosage levels. However, when orally administered, tilmicosin does not cause toxic reactions.Two trials were conducted to test the ability of tilmicosin as a feed additive to prevent transmission of progressive atrophic rhinitis (AR), involving P. multocida, from endemically affected pigs to AR-free pigs. The test pigs were 3 weeks old at the start of the trial.Tilmicosin fed continuously over 6 weeks at concentrations of 200 g per ton of feed controlled transmission of AR both in Trials I and 2.Weight gains were positively affected, and there were fewer nasal swabs positive for P. multocida at the end of the study period.
Keywords: Pasteurella multocida, atrophic rhinitis
Cite as: Bäckström L, McDonald J, Collins MT, et al. Efficacy of tilmicosin, and a combination of tylosin and sulfamethazine, for control of swine atrophic rhinitis involving infection with toxigenic Pasteurella multocida type D. J Swine Health Prod 1994;2(4):11-14.
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